' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.8
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
Top Medical Research Studies
8
Folic acid alleviates bone pain
Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats.
Direct investigation of folate impact
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Read More
8
Folic acid supports bone health
Effects of High and Low Doses of Folic Acid on the Soluble Receptor Activator of Nuclear Factor-kappa B Ligand/Osteoprotegerin Ratio during Pregnancy.
Significant impact on bone markers
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Read More
Most Useful Reviews
9.5
Relief from pain
I highly recommend it. After exercising, I often feel tired and experience bone pain. Taking this product helps me recover, and I feel fine by the next day. My mother also uses it for her hands, which often hurt from cleaning and cooking. After taking a pill, she wakes up pain-free the next day. I was advised by a doctor to use it, as it has numerous benefits, including energy restoration and relief from bone pain.
Read More
9.5
Reduced pain levels
This is an excellent tool! B vitamins are beneficial for lowering cholesterol, aiding digestion, and reducing pain. They have also been shown to improve the healing of wounds and overall skin condition. Since they are water-soluble, it's essential to include vitamin-rich foods in my diet to avoid bone pain and other issues.
Read More
10
Tooth pain relief
This product was recommended after discovering my vitamin B12 deficiency as a vegan. Since starting it, I have seen a marked improvement in my tooth pain. The quality is high, and it dissolves easily under the tongue. I appreciate that it also includes vitamin B6 and folic acid, which is beneficial.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
8
Folic acid alleviates bone pain
Folic acid relieves bone cancer pain by downregulating P2X2/3 receptors in rats.
Direct investigation of folate impact
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Read More
8
Folic acid supports bone health
Effects of High and Low Doses of Folic Acid on the Soluble Receptor Activator of Nuclear Factor-kappa B Ligand/Osteoprotegerin Ratio during Pregnancy.
Significant impact on bone markers
We undertook a study to investigate the effects of different doses of folic acid on bone health during pregnancy, particularly focusing on bone resorption markers associated with osteoporosis. In this randomized, double-blind trial, forty-five pregnant women participated, with some taking a high dose of 5 mg per day and others taking a lower dose of 0.5 mg per day throughout their pregnancy.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Our findings indicated that higher doses of folic acid appeared to help lower important markers of bone resorption, namely soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) and Tumor Necrosis Factor alpha (TNFα), while increasing Osteoprotegerin (OPG). This balance may contribute to improved bone health, potentially reducing the risk of Pregnancy Associated Osteoporosis (PAO) in affected women.
While the study did not directly measure bone pain outcomes, the biochemical changes observed suggest an encouraging approach to support bone health and prevent complications that can lead to pain and fractures. Overall, we believe that higher folic acid doses during pregnancy may offer beneficial effects on bone metabolism, thus contributing positively to women’s health in this crucial period.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.8
10
Tooth pain relief
This product was recommended after discovering my vitamin B12 deficiency as a vegan. Since starting it, I have seen a marked improvement in my tooth pain. The quality is high, and it dissolves easily under the tongue. I appreciate that it also includes vitamin B6 and folic acid, which is beneficial.
Read More
9.5
Relief from pain
I highly recommend it. After exercising, I often feel tired and experience bone pain. Taking this product helps me recover, and I feel fine by the next day. My mother also uses it for her hands, which often hurt from cleaning and cooking. After taking a pill, she wakes up pain-free the next day. I was advised by a doctor to use it, as it has numerous benefits, including energy restoration and relief from bone pain.
Read More
9.5
Reduced pain levels
This is an excellent tool! B vitamins are beneficial for lowering cholesterol, aiding digestion, and reducing pain. They have also been shown to improve the healing of wounds and overall skin condition. Since they are water-soluble, it's essential to include vitamin-rich foods in my diet to avoid bone pain and other issues.
Read More
9.5
Nerve pain improvement
I often experienced nerve pain, but after using this product, I've noticed significant improvement. I highly recommend it as it is both effective and reasonably priced.
9.5
Supports bone health
This product is excellent for bone health and provides much-needed vitamins for my bones. I’m very satisfied with the results.
